This annual edition of Large Truck and Bus Crash Facts contains descriptive statistics about fatal, injury, and property damage only crashes involving large trucks and buses in 2021. Selected crash statistics on passenger vehicles are also presented for comparison purposes. The report is organized into four chapters: Trends, Crashes, Vehicles, and People. The Trends chapter shows data for 2021 in the context of available historical data for past years. In the other chapters, the 2021 data are shown in different ways, according to what is being counted. Three-year trends in fatal crashes are presented for historical perspective when appropriate. The Crashes chapter counts numbers of crashes; the Vehicles chapter counts vehicles in crashes; and the People chapter counts persons of all types involved in crashes.